Mass spectrometry has played an increasingly important role in new drug research and development.

    Mass Spectrometry (GC-MS) combine two powerful techniques in order to provide the identification of compounds that have low detection limits and potential required for quantitative analysis. Gas Chromatography Mass Spectrometry analyses works on liquids, solid and gaseous samples but are primarily restricted to semi volatile and volatile compounds.

Under Gas Chromatography, a sample is carried and volatilized and carried by the inter gases through a coated glass Capillary Column. The stationary phase is joined to the interior of the column and the amount of time it takes a specific compound of an element to pass through this column on to a detector is called its "Retention Time". These measurements are used for identification purpose when compared to references.mass spec service

Under usual Mass Spectrometry or MS step under the Gas Chromatography Mass Spectrometry, the compounds leaving the GC columns are fragmented by the electron impact. These charged fragments are detected gradually and the subsequent spectrum obtained is used to identify the molecules. Fragmentation patterns are reproducible and thus, can be used to create quantitative measurements.

Gas Chromatography Mass Spectrometry analysis is performed on gases, solids and liquids. For gases and liquids, the samples are usually injected directly into the Gas Chromatogram. For the solid elements, the analysis is carried our through outgrassing or desorption, solvent extraction or pyrolysis. Desorption experiment is performed under the flow of helium gas at controlled temperature ranging between 40 to 300 degree Celsius. The analytes are then collected on a Cryogenic trap during desorption process. The sample chamber is a 1.25"x4" cylinder.

Pyrolysis is yet another sampling technique used for the analysis of materials that are impossible to be directly injected into Gas Chromatography Mass Spectrometry. Under this process, heat is directly applied to the sample that results in breaking down of the molecules in a reproducible way. These smaller molecules are then introduced in the Gas Chromatogram and analyzed by the GC-MS. By this method, probe temperatures of up to 1400ºC can be used.

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